Wounds That Will Not Heal

Duodenal ulcers that will not heal.

Masters of Immunology Tumors: Wounds That Do Not Heal—Redux

Similarities between tumors and the inflammatory response associated with wound healing have been recognized for more than 150 years and continue to intrigue. Some years ago, based on our then recent discovery of vascular permeability factor (VPF)/ VEGF, I suggested that tumors behaved as wounds that do not heal. More particularly, I proposed that tumors co-opted the wound-healing response to i...

THE LINK BETWEEN INFLAMMATION AND CANCER Wounds that do not heal Cancer Treatment and Research

The link with chronic inflammation and cancer has been recognized for certain cancers for several decades. However, only recently has the biology of chronic inflammation begun to be understood, to the point that it may play a major role in tumour development. The biology of chronic inflammation has many similarities with that of wound healing. In particular, local cell mediated immunity is atte...

Milk’s Bioactive Ingredients Help Wounds Heal Faster

Milk’s Bioactive Ingredients Help Wounds Heal Faster  Milk contains biologically active ingredients, including white blood cells, antimicrobial proteins, and cell-signaling molecules, that influence immune function.  Milk from various mammals, including humans, has demonstrated positive effects in animal models on healing lesions of skin and eyes by stimulating and enhancing the body’s immune...

Cancers as wounds that do not heal: differences and similarities between renal regeneration/repair and renal cell carcinoma.

Cancers have been described as wounds that do not heal, suggesting that the two share common features. By comparing microarray data from a model of renal regeneration and repair (RRR) with reported gene expression in renal cell carcinoma (RCC), we asked whether those two processes do, in fact, share molecular features and regulatory mechanisms. The majority (77%) of the genes expressed in RRR a...